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Dr Melissa Brown
Recent Publications from 2001
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44 |
Theis, T., Skurray. R.A., and Brown, M.H. (2007) Identification
of suitable internal controls to study expression of a Staphylococcus
aureus multidrug resistance system by quantitative real-time PCR.
Journal of Microbiology Methods doi:10.1016/j.mimet.2007.05.011. |
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43 |
Hassan, K.A., Skurray, R.A., and Brown, M.H. (2007)
Staphylococcal drug transport proteins Journal of Molecular
Microbiology and Biotechnology 12: 180-196 |
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42 |
Jensen, S.O., Guan, F., Kwong, S.M. Berg, T., Brown, M.H.,
Skurray, R.A. and Firth, N. (2007) Global regulation of survival
functions in conjugative staphylococcal multiresistance plasmids.
Plasmid 57: 197-198 |
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41 |
Hassan, K.A., Robinson, K.L., Smith A.N., Gibson, J.H., Skurray,
R.A. and Brown, M.H. (2006) Glycine-rich transmembrane helix 10 in the
staphylococcal TetA(K) tetracycline transport protein lines a solvent
accessible channel. Biochemistry 45: 15661-15669 |
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40 |
Hassan, K.A., Galea, M., Wu, J., Mitchell, B.A., Skurray, R.A.
and Brown, M.H. (2006) Functional effects of intramembranous proline
substitutions in the staphylococcal multidrug transporter QacA. FEMS
Microbiology Letters 263: 76-85 |
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39 |
Saidijam, M, Benedetti, G., Ren, Q.H., Xu, Z.Q, Hoyle, C.J.,
Palmer, S.L., Ward, A., Bettaney, K.E., Szakonyi, G., Meuller, J.,
Morrison, S., Pos, M.K., Butaye, P., Walravens, K., Langton, K.,
Herbert, R.B., Skurray, R.A, Paulsen, I.T., O’Reilly, J.,
Rutherford, N.G., Brown, M.H., Bill, R.M. and Henderson, P.J.F. (2006)
Microbial drug efflux proteins of the major facilitator superfamily.
Current Drug Targets 7: 793-811 |
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38 |
Bayer, A.S., Kupferwasser, L.I. Brown, M.H., Skurray, R.A.,
Grkovic, S,. Jones, T. Mukhopadhay, K. and Yeaman, M.R. (2006) Low-level
Staphylococcus aureus resistance to thrombin-induced platelet
microbicidal protein-1 (tPMP-1) in vitro associated with qacA
gene carriage is independent of multidrug efflux pump activity.
Antimicrobial Agents and Chemotherapy 50: 2448-2454 |
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37 |
Xu, Z., O'Rourke, B., Skurray, R.A. and Brown, M.H. (2006) Role
of transmembrane segment 10 in efflux mediated by the staphylococcal
multidrug transport protein QacA. Journal of Biological Chemistry
281: 792-799 |
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36 |
Grkovic, S., Hardie, K.M., Brown, M.H. and Skurray, R.A. (2003)
Interactions of the QacR multidrug-binding protein with structurally
diverse ligands; implications of the evolution of the binding pocket.
Biochemistry 42: 15226-15236 |
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35 |
Grkovic, S., Brown, M.H., Hardie, K. M., Firth, N. and Skurray,
R.A. (2003) Stable low copy-number Staphylococcus aureus shuttle
vectors. Microbiology 149: 784-794 |
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34 |
Brown, M.H. and Skurray, R.A. (2002) Structure, function and
regulation of the staphylococcal multidrug efflux protein QacA. In:
Microbial Multidrug Efflux (Paulsen, I.T. and Lewis, K., eds) pp.
49-66 Horizon Scientific Press, Wymondham. |
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33 |
Grkovic, S., Brown, M.H. and Skurray, R.A. (2002)
Regulation of bacterial drug export systems. Microbiology and
Molecular Biology Reviews 66: 671-701 |
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32 |
Schumacher, M.A., Miller, M.C., Grkovic, S., Brown, M.H.,
Skurray, R.A. and Brennan R.G. (2002) Structural basis for cooperative
DNA binding by two dimers of the multidrug binding protein QacR. The
EMBO Journal 21: 1210-1218 |
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31 |
Schumacher, M.A., Miller, M.C., Grkovic, S., Brown, M.H.,
Skurray, R.A. and Brennan R.G. (2001) Structural mechanisms of QacR
induction and multidrug recognition. Science 294:
2158-2163 |
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30 |
Grkovic, S., Brown, M.H., Schumacher, M.A., Brennan R.G., and
Skurray, R.A. (2001) The staphylococcal QacR multidrug regulator binds a
correctly spaced operator as a pair of dimers. Journal of
Bacteriology 183: 7102-7109 |
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29 |
Grkovic, S., Brown. M.H. and Skurray, R.A. (2001) Transcriptional
regulation of multidrug efflux pumps in bacteria. Seminars in Cell
and Developmental Biology 12: 225-237 |
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28 |
Brown, M.H. and Skurray, R.A. (2001) Staphylococcal multidrug
efflux protein QacA. Journal of Molecular Microbiology and
Biotechnology 3: 163-170 |
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27 |
Skurray, R.A. and Brown, M.H. (2001) Plasmid-mediated multidrug
resistance. Plasmid 45: 167-168 |
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