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Dr Melissa Brown

Recent Publications from 2001

44

Theis, T., Skurray. R.A., and Brown, M.H. (2007) Identification of suitable internal controls to study expression of a Staphylococcus aureus multidrug resistance system by quantitative real-time PCR. Journal of Microbiology Methods doi:10.1016/j.mimet.2007.05.011.

43

Hassan, K.A., Skurray, R.A., and Brown, M.H. (2007) Staphylococcal drug transport proteins Journal of Molecular Microbiology and Biotechnology 12: 180-196

42

Jensen, S.O., Guan, F., Kwong, S.M. Berg, T., Brown, M.H., Skurray, R.A. and Firth, N. (2007) Global regulation of survival functions in conjugative staphylococcal multiresistance plasmids. Plasmid 57: 197-198

41

Hassan, K.A., Robinson, K.L., Smith A.N., Gibson, J.H., Skurray, R.A. and Brown, M.H. (2006) Glycine-rich transmembrane helix 10 in the staphylococcal TetA(K) tetracycline transport protein lines a solvent accessible channel. Biochemistry 45: 15661-15669

40

Hassan, K.A., Galea, M., Wu, J., Mitchell, B.A., Skurray, R.A. and Brown, M.H. (2006) Functional effects of intramembranous proline substitutions in the staphylococcal multidrug transporter QacA. FEMS Microbiology Letters 263: 76-85

39

Saidijam, M, Benedetti, G., Ren, Q.H., Xu, Z.Q, Hoyle, C.J., Palmer, S.L., Ward, A., Bettaney, K.E., Szakonyi, G., Meuller, J., Morrison, S., Pos, M.K., Butaye, P., Walravens, K., Langton, K., Herbert, R.B., Skurray, R.A, Paulsen, I.T., O’Reilly, J., Rutherford, N.G., Brown, M.H., Bill, R.M. and Henderson, P.J.F. (2006) Microbial drug efflux proteins of the major facilitator superfamily. Current Drug Targets 7: 793-811

38

Bayer, A.S., Kupferwasser, L.I. Brown, M.H., Skurray, R.A., Grkovic, S,. Jones, T. Mukhopadhay, K. and Yeaman, M.R. (2006) Low-level Staphylococcus aureus resistance to thrombin-induced platelet microbicidal protein-1 (tPMP-1) in vitro associated with qacA gene carriage is independent of multidrug efflux pump activity. Antimicrobial Agents and Chemotherapy 50: 2448-2454

37

Xu, Z., O'Rourke, B., Skurray, R.A. and Brown, M.H. (2006) Role of transmembrane segment 10 in efflux mediated by the staphylococcal multidrug transport protein QacA. Journal of Biological Chemistry 281: 792-799

36

Grkovic, S., Hardie, K.M., Brown, M.H. and Skurray, R.A. (2003) Interactions of the QacR multidrug-binding protein with structurally diverse ligands; implications of the evolution of the binding pocket. Biochemistry 42: 15226-15236

35

Grkovic, S., Brown, M.H., Hardie, K. M., Firth, N. and Skurray, R.A. (2003) Stable low copy-number Staphylococcus aureus shuttle vectors. Microbiology 149: 784-794

34

Brown, M.H. and Skurray, R.A. (2002) Structure, function and regulation of the staphylococcal multidrug efflux protein QacA. In: Microbial Multidrug Efflux (Paulsen, I.T. and Lewis, K., eds) pp. 49-66 Horizon Scientific Press, Wymondham.

33

Grkovic, S., Brown, M.H. and Skurray, R.A. (2002) Regulation of bacterial drug export systems. Microbiology and Molecular Biology Reviews 66: 671-701

32

Schumacher, M.A., Miller, M.C., Grkovic, S., Brown, M.H., Skurray, R.A. and Brennan R.G. (2002) Structural basis for cooperative DNA binding by two dimers of the multidrug binding protein QacR. The EMBO Journal 21: 1210-1218

31

Schumacher, M.A., Miller, M.C., Grkovic, S., Brown, M.H., Skurray, R.A. and Brennan R.G. (2001) Structural mechanisms of QacR induction and multidrug recognition. Science 294: 2158-2163

30

Grkovic, S., Brown, M.H., Schumacher, M.A., Brennan R.G., and Skurray, R.A. (2001) The staphylococcal QacR multidrug regulator binds a correctly spaced operator as a pair of dimers. Journal of Bacteriology 183: 7102-7109

29

Grkovic, S., Brown. M.H. and Skurray, R.A. (2001) Transcriptional regulation of multidrug efflux pumps in bacteria. Seminars in Cell and Developmental Biology 12: 225-237

28

Brown, M.H. and Skurray, R.A. (2001) Staphylococcal multidrug efflux protein QacA. Journal of Molecular Microbiology and Biotechnology 3: 163-170

27

Skurray, R.A. and Brown, M.H. (2001) Plasmid-mediated multidrug resistance. Plasmid 45: 167-168

 

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