Dr Catherine Abbott

Publications

Students under Dr Abbott’s supervision are indicated by grey font.

2006

Chen T, Ajami K, McCaughan GW, Gai WP, Gorrell MD, Abbott CA Molecular characterization of a novel dipeptidyl peptidase like 2-short form (DPL2-s) that is highly expressed in the brain and lacks dipeptidyl peptidase activity. Biochimica et Biophysica- Proteins and Proteomics 1764: 33-43 (2006)

Sanderson MP, Abbott CA, Tada H, Seno M, Dempsey PJ, Dunbar AJ. Hydrogen peroxide and endothelin-1 are novel activators of betacellulin ectodomain shedding  J of Cell Biochem 99 (2): 609-623 (2006)

Sulda M, Abbott CA and Hildebrant M. DPIV/CD26 and FAP in cancer: a tale of contradictions. Dipeptidyl Aminopeptidases Basic Science and Clinical Applications Series: Advances in Experimental Medicine and Biology, Vol. 575, U Lendeckel, D Reinhold Eds. ISBN: 0-387-29058-3. Springer NY, 197-206 (2006)

Abbott CA, Yazbek R, Geier MS, Demuth HU and Howarth GS. Dipeptidyl peptidases and inflammatory bowel disease. Dipeptidyl Aminopeptidases Basic Science and Clinical Applications Series: Advances in Experimental Medicine and Biology, Vol. 575, U Lendeckel, D Reinhold Eds. ISBN: 0-387-29058-3. Springer NY, 155-162(2006)

Pitman M, Menz and Abbott CA. Prediction of dipeptidyl peptidase (DP) 8 structure by homology modeling. Dipeptidyl Aminopeptidases Basic Science and Clinical Applications Series: Advances in Experimental Medicine and Biology, Vol. 575, U Lendeckel, D Reinhold Eds. ISBN: 0-387-29058-3. Springer NY, 33-42 (2006)

Wilson C, Tyskin A, Wilkinson C, Abbott CA. Experimental design and analysis of microarray data. In Elsevier Science International series on Applied Mycology & Biotechnology  (Volume 6: Bioinformatics) Ed, Dilop Arora. In press 2006

2005

Geier MS, Abbott CA*, Tenikoff D, McCaughan GW, Howarth GS*. Development and resolution of experimental colitis in mice with targeted depletion of dipeptidyl peptidase IV Journal of Cellular Physiology.204: 687-92(2005) *Equal senior authorship.

2004

Chen T, Smyth D and Abbott CA, CD26 a review Journal of Biological Regulators and Homeostatic Agents 18:47-54 (2004)

Ajami K, Abbott CA, McCaughan GW & MD Gorrell. Dipeptidyl peptidase (DP) 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity Biochimica et Biophysica Acta-Gene structure and Expression. 1679(1)18-28(2004)

2003

Ajami K, Abbott CA, Obradovic M, Gysbers V, Kahne T, McCaughan GW and Gorrell MD. Structural requirements for catalysis, expression and dimerisation in the CD26/DPPIV gene family, Biochemistry-US, Jan 28;42(3):694-701(2003)

Ajami K, Abbott CA, Gysbers V, Kähne T, McCaughan, GW and Gorrell MD Molecular chimeras and mutational analysis in the prolyl oligopeptidase gene family. Dipeptidyl aminopeptidases in health and disease: Advances in Experimental Medicine and Biology, Vol. 524, M Hildebrandt, B. F. Klapp, T. Hoffman, H.-U. Demuth Eds, ISBN 0-306-47717-3. Kluwer, NY, 49-55 (2003).

Chen T, Ajami K, McCaughan GW, Gorrell MD and Abbott CA Dipeptidyl Peptidase IV gene family. Dipeptidyl aminopeptidases in health and disease: Advances in Experimental Medicine and Biology, Vol. 524, M Hildebrandt, B. F. Klapp, T. Hoffman, H.-U. Demuth. Eds, ISBN 0-306-47717-3. Kluwer, NY, 79-86 (2003).

 
2002

Abbott CA and Gorrell MD. The Family of CD26/DPIV and Related Ectopeptidases - The DPIV Family in Ectopeptidases: CD13/aminopeptidases N and CD26/Dipeptidyl peptidase IV in medicine and Biology, Kluwer Academic New York, 171-195 (2002)

Shackel NS, McGuiness PH, Abbott CA, Gorrell MD and McCaughan GW. Insights into the pathobiology of hepatitis C virus associated cirrhosis: analysis of intrahepatic differential gene expression, Am J Pathol 160: 641-654 (2002)

Wang M, Gorrell MD, Abbott CA, Jaggi R, Marguet D & Dickinson RG. Hepatic covalent adduct formation with zomepirac in the CD26-deficient mouse. Journal of Gastroenterology and Hepatology 17, 66-71 (2002)

2001

Shackel NS, McGuiness P, Abbott CA, Gorrell MD and McCaughan GW. Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis: cDNA array analysis of intrahepatic differential gene expression, Gut 49:565-576 (2001)

2000

Abbott CA, Yu DM, Woollatt E, Sutherland GR, McCaughan GW, Gorrell M. 2000 Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8. Eur J Biochem 267:20, 6140-50.

Gorrell MD, Abbott CA, Kähne T, Levy MT, Church WT and McCaughan GW. 2000 Relating structure to function in the beta-propeller domain of dipeptidyl peptidase IV: Point mutations that influence adenosine deaminase binding, antibody binding and enzyme activity. Adv Exp Med Biol. 477:89-95.

Abbott CA, McCaughan GW and Gorrell MD 2000. Post proline peptidases having DP IV like enzyme activity. Adv Exp Med Biol . 477:103-9.

McCaughan GW, Gorrell MD, Bishop GA, Abbott CA, et al. 2000 Molecular pathogenesis of Liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance. Immunol Rev. 174:172-91.

1999

Levy MT, McCaughan GW, Abbott CA, Park JE, Cunningham A, Mueller E, Rettig WJ, Gorrell MD. 1999 Fibroblast activation protein: A cell surface dipeptidyl peptidase and gelatinase expressed by stellate cells at the tissue remodelling interface in human cirrhosis. Hepatology 29:6, 1768-1778

Abbott CA, McCaughan GW and Gorrell MD. 1999 Two highly conserved glutamic acid residues in the predicted b propeller domain of dipeptidyl peptidase IV are required for its enzyme activity. FEBS Letters 458:3, 278-284

Abbott CA, Levy MT, McCaughan GW, Church B and Gorrell MD. 1999 Adenosine deaminase and antibodies that inhibit binding by this ligand have distinct, discontinuous binding sites on the beta-propeller domain of human CD26. European Journal of Biochemistry 266: 3, 798-810

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